New report on Exocrine Pancreatic Insufficiency (EPI) is an inability of proper digestion of food owing to insufficient levels of digestive enzymes from pancreas. EPI is commonly found in humans affected with Shwachman-Diamond Syndrome and cystic fibrosis. EPI is triggered by the progressive loss of pancreatic cells, which generates the digestive enzymes. EPI disturbs the normal growth, life expectancy and immune response. Diarrhoea, Steatorrhea, fatigue and weight loss are the key symptoms of EPI.
However, in the painful chronic exocrine pancreatitis, high dose protease are estimated to be beneficial. Individual pancreatic replacement therapy along with pancreatin medication is advised to the patient in severe cases. According to the research conducted by Robbins basic pathology, exocrine pancreatic insufficiency was observed to occur in the 85% to 90% of patients with cystic fibrosis in 2013.
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Pancreatic replacement therapy in EPI is an extensively accepted mode of treatment and aids in minimizing the malabsorption and related malnutrition. Primarily, these pancreatic digestive enzymes include lipase for the fat digestion, protease for the protein digestion, and amylase for the starch digestion in the body. Following pancreatic enzyme products (PEPs) were approved by USFDA for the treatment of EPI: Zenpep and Creon in 2009, Viokace and Ultresa in 2012, Pancreaze in 2010, and Pertzye in 2012. In developed regions, rising geriatric population, minimum death rates and are the key factors driving the incidences of EPI. Enhanced demand for the advanced therapeutics and rising percentage geriatric population affected population are other factors responsible for the growth of this market.
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MARKET BY DISEASE MANAGEMENT
- Nutritional management
- Pancreatic enzyme replacement therapy (PERT)
- Life style modifications approach
MARKET BY DIAGNOSIS
- Magnetic resonance imaging (MRI)
- CT scanning
- Endoscopic ultra-sonography (EUS)
- Blood tests
- Other tests
MARKET BY GEOGRAPHY
- North America
- Asia Pacific
- Europe
- LAMEA
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